Computational molecular modeling tools have proven to be effective in antibody development and are increasingly used throughout the antibody discovery industry. Our company offers customers a professional offering of antibody design and modification services that can be customized for their innovative scientific research. Each project is evaluated individually before analytical advice and fees are provided. Our high-quality antibody design and modification services provide trusted results for our customers' experiments and other downstream applications.
Service Overview
Our company's experts have strong capabilities and extensive experience in antibody design and modification. We can build an antibody simulation platform in a short period of time and complete high-quality antibody design and modification services based on it.
In addition to mastering the theoretical principles and operating methods of various mainstream simulation software commonly used in the industry, we also have a variety of original molecular simulation programs that can perform a variety of unique and efficient molecular transformation tasks.
Overall Solutions
Our company is an international company to provide complete solutions in the field of rational antibody design, covering:
(1) Annotation of antibody sequences: annotation of the variable, constant and CDR regions of antibody heavy and light chains, identification of antibody germline genes.
(2) Analysis of antibody sequences: prediction of post-translational modification sites of antibodies (e.g. glycosylation sites), prediction of antigenic linear epitopes.
(3) Prediction and optimization of antibody structures: structure prediction and modeling of full-length antibodies, antibody Fab regions, SCFv, bispecific antibodies, etc.
(4) Prediction of antibody-antigen interactions: antigen-antibody docking, identification of antigen conformational epitopes, determination of semi-antigenic linkage sites.
(5) Design and modification of antibody molecules: antibody affinity maturation, antibody stability optimization, expression optimization, bispecific antibody design, antibody aggregation effect analysis.
(6) Antibody humanization design, immunogenicity prediction, electrostatic potential surface construction.
Research Capabilities
- Antibody library design based on antigen function tables
We have adopted an approach to antibody library design based on antigen functional table positions.
First, statistical and experimental data can be analyzed by computer simulation. These empirical data can be reduced to specific antibody models and evaluated for each position, including specificity, affinity and stability.
Based on the information obtained, the relative capacity of the library can be constructed, such as a small, high-quality antibody library with a high percentage of effective clones, increasing the screening efficiency.
Second, ab initio design methods for antibody libraries can be used.
- Ab initio design of antibodies
Provided that the crystal structure of the antigen is known, or a high-precision antigen model is available, we can use computer simulations to design new antibodies against the antigen.
The main advantage of this technique is that, provided the antigen structure is known, parent antibodies with a certain affinity can be rapidly obtained.
- Computer-assisted antibody affinity maturation
In addition to traditional phage display techniques, we have a range of effective computer-assisted antibody affinity maturation techniques, including virtual alanine scanning and virtual saturation mutagenesis.
- Computer-assisted half-life transformation
After a certain level of antibody stability, the half-life of an antibody in vivo is mainly determined by its elimination rate in vivo. By analyzing the elimination mechanism of antibodies in vivo, we developed three methods to slow down the elimination rate. The Fc-FcRn affinity maturation method, charge redistribution method and affinity conversion method.
If you are looking for smarter, higher quality solutions that incorporate best practices, please feel free to contact us.
Related Services
It should be noted that our service is only used for research, not for clinical use.
