Coated microneedles are advanced medical devices designed for transdermal drug delivery, offering a minimally invasive alternative to traditional hypodermic needles. These tiny, micron-sized needles are typically fabricated from biocompatible materials and are coated with therapeutic agents (such as vaccines, peptides, proteins, or other drugs), allowing for efficient penetration of the skin barrier. When applied to the skin, the microneedles create microchannels that facilitate the diffusion of the coated substance into the systemic circulation, enhancing bioavailability and providing precise dosing. This innovative technology holds promise for improving patient comfort, adherence, and the overall efficacy of various therapeutics, including vaccines, insulin, and other biologics.
Fig.1. Schematic illustration of coated microneedles.
At our company, we have developed coated microneedle technology platform. This cutting-edge transdermal drug delivery system is designed to overcome traditional challenges of oral administration and hypodermic injection and redefines how therapeutics is administered.
Our Coated Microneedle Technology Platform
Our coated microneedle technology platform is built on a combination of advanced microfabrication and precision coating techniques. At the heart of platform lies a highly engineered coating process that ensures consistent, precise, and efficient drug delivery. This process is critical to achieving uniform drug distribution across microneedles while maintaining the stability and bioactivity of the active pharmaceutical ingredient (API).
Precision Application for Uniform Coverage
We employ advanced, highly controllable coating techniques to apply ultra-thin layers of the drug formulation onto the microneedle surface. Our techniques include:
- Dip-coating
- Gas jet drying method
- Spray-coating
- Ultrasonic spray
These techniques are selected based on the physicochemical properties of the API, desired dose, and delivery profile. Our process is optimized to ensure:
- Uniform coating thickness across all microneedles in an array
- Consistent drug loading from patch to patch
- Minimal coating loss or variability during handling and packaging
Optimized Formulation for Stability and Performance
Each microneedle coating is carefully formulated to ensure that the drug remains stable, effective, and rapidly dissolves upon skin contact. Our formulation process combines pharmaceutical expertise with deep knowledge of material science to create a coating that works reliably under real-world conditions. A typical coating includes:
- The active drug in a dry, stable form (solid or crystalline)
- Film-forming polymers (such as PVP or HPMC), which help the coating stick to the microneedles and dissolve quickly once applied to the skin
- Stabilizing agents and pH buffers, which protect the drug during manufacturing and storage—especially important for temperature-sensitive biologics
- Optional enhancers or adjuvants, depending on the drug type and therapeutic goal (e.g., improved skin absorption or stronger immune response)
Our formulation team tailors each coating matrix to ensure maximum stability, skin compatibility, and delivery efficiency, even for sensitive biologics like peptides, proteins, or mRNA.
Rapid Dissolution for Effective Delivery
Upon application to the skin, the coated microneedles painlessly penetrate the stratum corneum. The thin coating dissolves within seconds to minutes, enabling rapid uptake of the API into dermal capillaries or immune-responsive regions of the skin.
This fast-release profile makes our microneedle platform ideal for indications where speed of onset and systemic absorption are critical—such as vaccination, pain relief, or acute therapies.
Key Advantages of Platform: High Precision Dosing
Each microneedle patch is pre-loaded with a precise quantity of drug during the coating process, ensuring consistent and accurate dosing across applications. This is especially critical in sensitive use cases such as biologics and vaccines.
Services at Our Platform
Our coated microneedle technology platform is a comprehensive innovation hub offering end-to-end services for partners seeking to develop, evaluate, and commercialize microneedle-based therapies. Whether you are a pharmaceutical company developing a new biologic, or a biotech startup seeking a novel delivery route, we provide tailored support at every stage:
- Formulation Development: We offer custom coating formulation design for a wide range of APIs. Our formulation scientists work closely with your team to select optimal excipients, determine target dose loading, and ensure physical and chemical stability of the coating.
- Microneedle Design & Customization: We provide a library of validated microneedle designs as well as custom geometries based on the required mechanical strength, skin insertion depth, and drug loading. Services include:
- Material selection (polymeric, metallic, or biodegradable)
- Array density and configuration optimization
- Insertion force simulation and mechanical testing
- Prototype Manufacturing & GMP Scale-Up: We support pilot-scale batch production for preclinical and early-phase clinical trials, with the ability to scale to GMP-compliant manufacturing through our facilities.
Contact Us to explore partnership opportunities or to learn more about how our coated microneedle platform can support your therapeutic innovations.
Related Services
It should be noted that our service is only used for research, not for clinical use.
