Microneedle technology is a dosage form technology and an innovative way of drug delivery, and it can penetrate the outer layer of the skin (the stratum corneum) to deliver drugs, vaccines, or other therapeutic agents directly into the dermis or subdermal layers, where they can achieve better absorption and efficacy. Typically ranging from 25 to 1500 micrometers in length, microneedles are not deep enough to cause significant pain or bleeding, making them a less invasive alternative to traditional hypodermic needles. Nowadays, microneedle drug has been regarded as an innovative form of pharmaceutical preparation and has received wide attention. Dissolving microneedle technology, a subset of this field, presents an innovative method where the microneedles themselves are made from biodegradable polymers or sugars that dissolve after penetration. This feature ensures that the microneedles do not leave any waste behind, eliminating the risk associated with leftover sharp devices and making them extremely safe for both patients and healthcare providers [1].
At the forefront of this cutting-edge science, our company has established a comprehensive dissolving microneedle technology platform, offering comprehensive solutions for the development of microneedle-based therapies. Our platform integrates research, development, and production, utilizing advanced materials and engineering techniques to create customized microneedle products.
Drug Delivery Principle of Dissolving Microneedle
When the microneedles puncture the skin, they create microchannels that enable the drug loaded within the microneedles to diffuse into the interstitial fluid of the skin. As the microneedles dissolve, the encapsulated drug is released and absorbed by the surrounding tissue, enhancing bioavailability and therapeutic effectiveness. This method bypasses the gastrointestinal tract and first-pass metabolism, leading to improved absorption and reduced side effects.
Fig.1. Schematic diagram of the principle of dissolved microneedles.
Advantages of Dissolving Microneedle
- Safety and Patient Compliance: As opposed to traditional hypodermic needles, dissolving microneedles are painless and do not produce hazardous medical waste. This increases patient compliance, especially among those who are needle-phobic or require regular injections.
- Precision and Efficacy: These microneedles offer precise control over drug delivery in terms of depth and dosage. The dissolving feature ensures that the drug is released at a controlled rate, improving therapeutic efficacy.
- Versatility: Dissolving microneedles can be formulated to include a range of drugs, from small molecules to large proteins and vaccines, making them suitable for diverse medical applications.
- Stability and Storage: Drugs embedded within the microneedles are often more stable, reducing the need for refrigeration and making them suitable for resource-limited settings.
Our Dissolving Microneedle Technology Platform
Our company is a leader in the technology of painless transdermal drug delivery using dissolvable microneedles. We possess advanced high-precision microneedle mold preparation technology, stable automated and modular microneedle production, and a variety of water-soluble materials for microneedle fabrication, such as maltose, polyvinylpyrrolidone, polyethylene glycol, polylactic-glycolic acid copolymer (PLGA), polymethyl methacrylate (PMMA), chondroitin sulfate, dextran, hyaluronic acid, and albumin. Based on this, our platform can provide a comprehensive suite of services:
- Formulation Development: Our team of experts works collaboratively with clients to develop bespoke microneedle formulations that meet specific therapeutic objectives.
- Formulation Analysis: We can assess the physicochemical properties, stability, and performance of microneedle formulations.
- Process Research: Our process research services focus on optimizing the manufacturing processes of dissolving microneedles.
- Regulatory Support: Our regulatory team offers comprehensive support to help clients meet the necessary compliance standards for clinical trials and market approval.
In addition, at our dissolving microneedle platform, we can provide microneedle formulation related services for a wide range of biological macromolecules and highly active small molecule drugs, including:
Our dissolving microneedle technology platform represents a pioneering hub for innovation and collaboration in drug delivery. By bringing together cutting-edge technology, expert insights, and comprehensive services, we aim to advance the medical field and enhance patient outcomes through this transformative technology. If you are interested in our services or have any questions or needs, please feel free to contact us.
Reference
- Ita K. Dissolving microneedles for transdermal drug delivery: Advances and challenges[J]. Biomedicine & Pharmacotherapy, 2017, 93: 1116-1127.
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It should be noted that our service is only used for research, not for clinical use.
