Hollow microneedles are micron-scale needle structures with internal lumens that allow for the active delivery of liquid formulations directly into the dermis or subcutaneous tissue. Unlike solid microneedles, which rely on passive diffusion or coating dissolution, hollow microneedles provide a controlled, pressurized channel for drug transport. Each microneedle is fabricated to precisely penetrate the stratum corneum without stimulating nerve endings, thus ensuring a pain-free administration while achieving deep and reproducible drug penetration. These microneedles are typically fabricated from materials such as silicon, metals, and biodegradable polymers. Their development has opened up new avenues for transdermal drug delivery, particularly for vaccines, insulin, and other biologics that require precise dosing.
Fig.1. Schematic illustration of hollow microneedles.
At our company, we have developed hollow microneedle technology platform. This platform combines precision engineering, biocompatible materials, and scalable manufacturing to provide a painless, efficient, and highly targeted means of administering therapeutic agents across the skin barrier.
Advantages of Hollow Microneedle
- Minimized Pain and Discomfort: The use of hollow microneedles significantly reduces the pain associated with injections, improving patient compliance and experience.
- Improved Drug Absorption: The ability to deliver drugs directly into the dermal or subcutaneous layers enhances bioavailability and speeds up the onset of action.
- Precision and Control: It allows for precise control over dosage and delivery rates, reducing the risk of overdose and improving treatment efficacy.
- Versatility: It can be used for a wide array of therapeutic agents, making it a versatile solution for various medical applications.
- Reduced Risk of Infection: Due to their minimally invasive nature, hollow microneedles reduce the risk of skin infections and tissue damage.
Our Hollow Microneedle Technology Platform
We have established a cutting-edge hollow microneedle technology platform that integrates advanced microfabrication techniques, drug formulation science, and translational delivery system design. Our platform is built upon years of interdisciplinary research in materials science, microfluidics, and biopharmaceutical engineering. The core of our platform lies in a proprietary hollow microneedle design, which features:
- Optimized mechanical strength for reliable skin insertion
- Tunable inner channel diameters for controlled fluid flow
- Biocompatible and scalable materials including medical-grade polymers, silicon, and stainless steel
- Modular integration with micro-pumps, patches, and wearable drug delivery devices
Our R&D team continuously iterates on needle architecture and array configurations (single needle to high-density arrays) to enable enhanced drug absorption and retention. From low-molecular-weight drugs to monoclonal antibodies, peptides, mRNA, and DNA vaccines, our platform supports the precise delivery of both hydrophilic and hydrophobic compounds. The hollow channel permits instantaneous or programmable injection, offering flexibility for bolus, pulsed, or sustained release.
Services at Our Platform
To support drug developers and healthcare innovators, we offer a full suite of services through our hollow microneedle technology platform, including:
- Initial Concept and Design Development: We collaborate closely with clients to understand therapeutic goals and delivery requirements. This stage involves feasibility assessment, clinical context analysis, and definition of key technical specifications for hollow microneedle systems.
- Material Selection and Optimization: Based on the drug formulation, delivery mode, and mechanical performance needs, we evaluate and select the most suitable materials.
- Custom Microneedle Fabrication: We collaborate with clients to develop bespoke hollow microneedles tailored to the physicochemical properties of the target molecule (e.g., viscosity, molecular weight, stability). Our microfabrication facilities support prototyping with rapid turnaround.
- Formulation Compatibility Testing: Our formulation scientists work closely with your drug product to ensure compatibility with hollow microneedle injection. We evaluate flow rates, viscosity effects, and degradation profiles under simulated use conditions.
- Prototyping and Characterization Testing: Functional prototypes are fabricated for initial testing. We conduct comprehensive characterization including mechanical strength, flow rate testing, skin penetration efficiency, and drug delivery accuracy. Iterative improvements are made based on these evaluations.
As the field of transdermal drug delivery evolves, the importance of precision, patient comfort, and molecular compatibility becomes paramount. Our hollow microneedle technology platform is positioned at the forefront of this transformation, offering a robust, scalable, and patient-centric solution for next-generation therapeutics.
We welcome partnerships with pharmaceutical companies, biotech startups, research institutions, and device developers to explore the possibilities of microneedle-enabled drug delivery.
Related Services
It should be noted that our service is only used for research, not for clinical use.
