Hydrogel forming microneedles are micron-scale projections composed of crosslinked hydrophilic polymers. When applied to the skin, they painlessly pierce the stratum corneum and absorb interstitial fluid, forming a hydrogel matrix. This allows drugs in a separate reservoir to diffuse through the hydrogel into systemic circulation without leaving residual materials in the skin. Unlike dissolving or solid microneedles, hydrogel forming microneedles:
- Do not leave polymeric debris in the body
- Offer high biocompatibility
- Enable sustained and controlled release
- Support delivery of both small molecules and biologics
This makes them ideal for vaccines, peptides, proteins, nucleic acids, and other sensitive therapeutic agents.
Fig.1. Schematic illustration of hydrogel forming microneedles.
At our company, we are at the forefront of transdermal drug delivery innovation. One of our most promising advancements is the hydrogel forming microneedle technology platform, designed to overcome the limitations of conventional drug delivery systems and enable painless, efficient, and controlled administration of therapeutic agents through the skin.
Our Hydrogel Forming Microneedle Technology Platform
Core components of our technology platform are customizable hydrogel matrices and precision microfabrication technology that support end-to-end development of hydrogel microneedle products:
Customizable Hydrogel Matrices
We have developed a proprietary portfolio of crosslinkable polymers, including:
- Natural Polymer: (1) Natural polysaccharides such as chitosan, cellulose, hyaluronic acid, sodium alginate, cellulose and starch; (2) Proteins such as gelatin and silk fibroin; (3) Carbohydrate-protein polymers.
- Synthetic Polymer: Gelatin methacryloyl, methacrylate-based hyaluronic acid, polyvinyl alcohol, etc.
- Combined Natural and Synthetic Polymer
These can be tailored to control mechanical strength, regulate swelling rate, and modulate release kinetics. Moreover, our materials are optimized for skin penetration, minimal irritation, and consistent performance, enabling wide adaptability across therapeutic areas.
Precision Microfabrication Technology
Our cleanroom manufacturing facilities use micromolding, casting, electrospinning and 3D microfabrication techniques to produce high-fidelity microneedle arrays. We offer:
- Varying microneedle lengths (200-800 µm)
- Array densities (up to 400 needles/cm2)
- Optimized tip sharpness and geometry
This allows for reproducible skin insertion without pain or bleeding, making the platform suitable for self-administration.
Applications Across Therapeutic Areas
The versatility of our platform enables broad applicability across pharmaceutical and healthcare domains:
- Vaccination: Hydrogel microneedles are ideal for thermostable vaccine delivery, eliminating the need for cold chain logistics.
- Chronic Disease Management: Our system supports transdermal delivery of medications for diabetes (insulin), hormone replacement therapy, and hypertension, offering needle-free, self-administrable alternatives.
- Biologic Drug Delivery: Through advanced formulation strategies, our platform enables stable delivery of therapeutic peptides, proteins, and antibodies.
- Cosmeceuticals and Dermatology: Hydrogel microneedles are already being utilized for anti-aging, scar treatment, and hyperpigmentation therapies, offering enhanced skin penetration of active ingredients.
Services at Our Platform
As a full-scope technology provider, we offer a comprehensive range of services to accelerate your product development:
- Feasibility Studies and Proof-of-Concept: We work with partners to evaluate drug compatibility, skin permeation potential, and preliminary release profiles using our hydrogel microneedle platform.
- Formulation Development: Our formulation scientists optimize drug-reservoir combinations and hydrogel compositions for maximum bioavailability and stability.
- Microneedle Design and Prototyping: We provide custom microneedle design based on therapeutic needs, including geometry optimization, skin insertion testing, and in vitro drug release analysis.
- Analytical and Preclinical Testing: We offer skin permeation studies, pharmacokinetic analysis, biocompatibility testing of hydrogel microneedle.
The hydrogel forming microneedle technology platform is reshaping the landscape of transdermal drug delivery by combining pain-free administration with programmable, safe, and efficient drug transport. From early-stage research to scalable product development, our platform delivers robust solutions across multiple therapeutic areas. We invite partners to collaborate with us in advancing the next frontier of drug delivery. For more information or partnership inquiries, please contact us.
Related Services
It should be noted that our service is only used for research, not for clinical use.
