Every step in the drug development process includes preclinical pharmacokinetics. Finding the concentration of a medicine that is pharmacologically active in the target compartment is the main goal of preclinical pharmacokinetics. Toxicology research, formulation development, and dosing regimens all depend on this information.
Our company provides specialist in vitro pharmacokinetic services catered to our customers' cutting-edge scientific research thanks to its preclinical pharmacokinetic studies expertise. Before the proper analysis approach and pricing can be decided, each project must be assessed. Contact us at any time if you need further details.
Service Overview
Understanding the main physicochemical characteristics and structural patterns that influence a candidate compound's efficacy and safety is crucial in the early phases of drug research. Our company uses in vitro pharmacokinetics to describe absorption, distribution, metabolism, and excretion. In vitro pharmacokinetic analysis is essential for gaining insight into metabolism and potential drug interactions.
Our company offers in vitro pharmacokinetic services to analyze a compound's ADME qualities. Our in vitro evaluation program covers hepatic clearance prediction, chemical property assessment, protein binding assessment, membrane permeability assessment, reactive metabolite assessment, enzyme inhibitor assessment, enzyme induction assessment, and metabolic stability assessment.
Research Capabilities
- Physical and Chemical Characterization of Drugs
In the early stages of drug development, the physical and chemical properties of a compound should be evaluated. Our company can provide clients with services to study physical and chemical properties, including drug solubility, permeability, and in vitro stability.
(1) The candidate compound should be water-soluble so that it can be dissolved in blood/plasma and other body fluids.
(2) The compound is lipid-soluble so that it can be absorbed through biological membranes, such as the intestinal wall (especially for orally administered compounds).
(3) Stability is the basis for drug efficacy.
- Drug Interactions Related to Metabolic Enzymes
Metabolic elimination of many drugs (including most metabolism via the P450 enzyme system) can be inhibited, activated, or induced by combinations of drugs. The metabolic changes caused by drug interactions can be substantial. They may decrease or increase the concentration of the drug or its metabolites in the blood or tissues by an order of magnitude or more, and may also result in the production of toxic metabolites or exposure to toxic prototypes of the drug.
Our company can provide services for the study of several major P450 enzymes, including enzyme inhibition, enzyme induction, and enzyme phenotyping.
- In Vitro Characterization of Drug Metabolites
During the drug development process, the metabolic profile of a drug needs to be determined. Metabolic characterization can be accomplished at different stages of development by in vitro and in vivo testing methods. In vitro tests can be performed using liver microsomes, liver slices, or hepatocytes from different animals and humans. In vitro testing should usually be performed prior to the start of clinical trials.
Our company uses different types of liver microsomes, S9 components, and hepatocytes to culture the drug and to study the metabolism and transformation forms of the drug in vitro.
Fig.1. In vitro stability studies and pharmacokinetic studies of poly(ε-caprolactone)-based micelles loaded with photosensitizers. (Liu Y, et al. 2020)
Overall Solutions
| Project Name | In Vitro Pharmacokinetic Service |
| Service Details | - Determination of the plasma protein binding rate
- Plasma stability test
- Hepatic microsomal metabolism assay
- CYP450 inhibition test
- CYP450 sensing test
- Metabolite speculation and confirmation
- Metabolic pathway prediction and confirmation
- Transmembrane transport assay
- Drug interactions
- Metabolic phenotyping studies
- Hepatocyte metabolic stability assay
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| Deliverables | Within agreed time, we will provide the summary to experiment data and conclusions, as well as a final experiment report. |
| Cycle | Decide according to your needs. |
For more information, please feel free to contact us.
Reference
- Liu Y, et al. (2020). "Correlation between In Vitro Stability and Pharmacokinetics of Poly(ε-Caprolactone)-Based Micelles Loaded with A Photosensitizer." Journal of Controlled Release. 328: 942-951.
Related Services
It should be noted that our service is only used for research, not for clinical use.
