ALV2

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ALV2

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Catalog Number	PR2438124957
CAS	2438124-95-7
Description	ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment.
IUPAC Name	1-(3-chloro-4-methylphenyl)-3-[2-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]propan-2-yl]urea
Molecular Weight	523.97
Molecular Formula	C26H26ClN5O5
Canonical SMILES	O=C(NC(C)(C1=CC=CC(NC2=CC(N(C(CC3)C(NC3=O)=O)C2=O)=O)=C1)C)NC4=CC=C(C)C(Cl)=C4
InChI	InChI=1S/C26H26ClN5O5/c1-14-7-8-17(12-18(14)27)29-25(37)31-26(2,3)15-5-4-6-16(11-15)28-19-13-22(34)32(24(19)36)20-9-10-21(33)30-23(20)35/h4-8,11-13,20,28H,9-10H2,1-3H3,(H2,29,31,37)(H,30,33,35)
InChI Key	YKFHBIMJVFQOQL-UHFFFAOYSA-N
Purity	>98%
Appearance	White to yellow solid
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at -20 °C

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