| Description |
Benzbromarone is 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication. It has a role as a uricosuric drug. It is a member of 1-benzofurans and an aromatic ketone. It is functionally related to a 2,6-dibromophenol. |
| Synonyms |
Benzbromaron; Desuric; Urinorm; Normurat; Uricovac |
| IUPAC Name |
(3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone |
| Molecular Weight |
424.1 |
| Molecular Formula |
C17H12Br2O3 |
| InChI |
WHQCHUCQKNIQEC-UHFFFAOYSA-N |
| InChI Key |
InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3 |
| Drug Categories |
Antigout Preparations; Antirheumatic Agents; Benzofurans; BSEP/ABCB11 Substrates; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP2C19 inhibitors (strength unknown); Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors (strength unknown); Cytochrome P-450 Enzyme Inhibitors; Heterocyclic Compounds, Fused-Ring; Musculo-Skeletal System; OATP1B1/SLCO1B1 Inhibitors; Organic Anion Transporting Polypeptide 2B1 Inhibitors; Preparations Increasing Uric Acid Excretion; Uricosuric Agents |
| Drug Interactions |
Abrocitinib-The metabolism of Abrocitinib can be decreased when combined with Benzbromarone.
Acenocoumarol-The metabolism of Acenocoumarol can be decreased when combined with Benzbromarone.
Acetohexamide-The metabolism of Acetohexamide can be decreased when combined with Benzbromarone.
Acetylsalicylic acid-The therapeutic efficacy of Benzbromarone can be decreased when used in combination with Acetylsalicylic acid.
Albendazole-The metabolism of Albendazole can be decreased when combined with Benzbromarone. |
| Isomeric SMILES |
CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br |
| Standard |
CP, USP, EP |
| Therapeutic Category |
Antigout Agent |
| Type |
Small Molecule |
