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BMS-1166-N-piperidine-CO-N-piperazine

Name: BMS-1166-N-piperidine-CO-N-piperazine
SKU: PR2447066148
Rating: 5 (1 reviews)

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Catalog NumberPR2447066148

CAS Number2447066-14-8

CategoryTarget Protein Ligand-Linker Conjugates

Description	BMS-1166-N-piperidine-CO-N-piperazine is designed to serve as a crucial component in the synthesis of a novel PROTAC, known as PD-1/PD-L1 degrader-1. This compound incorporates a specific ligand targeting the PD-1/PD-L1 immune checkpoint and is linked via a PROTAC linker. Its primary purpose is to facilitate the creation of a degrader that effectively inhibits the interaction between PD-1 and PD-L1, demonstrating an IC50 of 39.2 nM, which highlights its potential for therapeutic applications in immune checkpoint modulation.
Molecular Weight	707.26
Molecular Formula	C41H43ClN4O5
Canonical SMILES	O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)N7CCNCC7
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere.

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