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BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Name: BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
SKU: PR2691796833
Rating: 5 (1 reviews)

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Catalog NumberPR2691796833

CAS Number2691796-83-3

CategoryTarget Protein Ligand-Linker Conjugates

Description	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is designed to target the PD-1/PD-L1 immune checkpoint by incorporating a ligand that interacts with these proteins and a PROTAC linker. Its primary purpose is to facilitate the synthesis of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits the PD-1/PD-L1 interaction, showcasing a potent inhibitory concentration (IC50) of 39.2 nM.
Molecular Weight	780.18
Molecular Formula	C41H45Cl3N4O5
Canonical SMILES	N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN6CCCCC6C(N7CCNCC7)=O)Cl)=C1.Cl.Cl
Purity	95.01%
Appearance	Solid
Color	White to off-white
Shipping	Room temperature in continental US; may vary elsewhere.

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