Caffeine Anhydrous

Trexler, Eric T., et al. European journal of sport science, 2016, 16(6), 702-710.

People who stay active use coffee and caffeine to boost their athletic abilities. The aim of this study was to compare the effects of acute coffee (COF) and caffeine anhydrous (CAF) ingestion on strength and sprint performance.
· Experimental Methods
Fifty-four resistance-trained men completed a strength test consisting of one repetition maximum (1RM) and repetitions to fatigue (RTF) of 80% 1RM on the leg press (LP) and bench press (BP). Participants then completed five 10-second cycle ergometer sprints separated by one-minute rest. Peak power (PP) and total work (TW) were recorded for each sprint. At least 48 hours later, participants returned and ingested a beverage containing CAF (300 mg fixed dose; yielding 3-5 mg/kg body weight), COF (8.9 g; 303 mg caffeine), or placebo (PLA; 3.8 g non-caloric flavoring) 30 minutes before testing.
· Results
Neither CAF nor COF improved strength outcomes compared to placebo. In trained men, 3-5 mg/kg of caffeine 30 minutes before exercise can improve high-intensity sprint performance. Anhydrous caffeine does not appear to enhance performance more than coffee. Coffee and anhydrous caffeine can be considered suitable caffeine sources before high-intensity exercise.

Jelvehgari, Mitra, et al. Pharmaceutical sciences, 2015, 21(2), 102-110.

In order to improve the oral bioavailability of ergotamine tartrate (ET), a rapidly dissolving oral ET/CA film delivery system was developed in this work, considering that caffeine (CA) can increase the speed and degree of water solubility of ET.
· Preparation of ET/CA Film
Rapidly dissolving films (ET and CA) were successfully prepared by solvent casting using low viscosity grade hydroxypropyl methylcellulose (HPMC E-15) as film-forming polymer and propylene glycol as plasticizer. The optimal drug/polymer ratios in ET/CA films were 1:20 (E2) and 1:4 (C2), respectively. The weights of E2 and C2 films were 9.9 and 3.2 mg, respectively, the thicknesses were 74 and 45 μm, respectively, the folding endurances were 120.66 and up to 300 times, and the drug contents were 0.38 and 0.52 mg/cm2, respectively.
· Performance of ET/CA Film
The average disintegration time of the optimized film was within 26-165 s, and the release was 59.09-101.34% within 2 h. The film was non-irritating, had good film properties, and showed sufficient mucoadhesion potential before the drug was absorbed from the formulation. In addition, it was demonstrated that the combination of ET and CA film for oral delivery can treat migraine, avoiding the disadvantages of the oral route.