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Desmorpholinyl Quizartinib-PEG2-COOH

Name: Desmorpholinyl Quizartinib-PEG2-COOH
SKU: PR2292116142
Rating: 5 (1 reviews)

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Catalog NumberPR2292116142

CAS Number2292116-14-2

CategoryTarget Protein Ligand-Linker Conjugates

Description	Desmorpholinyl Quizartinib-PEG2-COOH serves as a critical component in the development of a PROTAC that targets FLT-3, particularly through the incorporation of a ligand specific for FLT-3 and a specialized PEG-based linker. This product is utilized in the synthesis of PROTAC FLT-3 degrader 1, an innovative compound designed to effectively degrade FLT-3 internal tandem duplication (ITD) with an impressive IC50 of 0.6 nM.
Molecular Weight	607.68
Molecular Formula	C30H33N5O7S
Canonical SMILES	O=C(O)CCOCCOCCOC1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3
Purity	96.32%
Appearance	Solid
Color	Light yellow to yellow
Shipping	Room temperature in continental US; may vary elsewhere.

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