Indications
Dydrogesterone is prescribed for the management of menstrual irregularities due to progesterone deficiency, which includes addressing irregular cycle durations and unpredictable onset and cessation of periods. Additionally, it is utilized in preventing spontaneous abortion in patients with a history of recurrent miscarriages.
Pharmacodynamics
Dydrogesterone is an orally active progestogen, targeting the uterus to elicit the development of a secretory endometrium in an estrogen-prepared uterus. At therapeutic doses, dydrogesterone does not possess contraceptive properties, as it neither inhibits ovulation nor affects the corpus luteum. Furthermore, the drug is characterized by its lack of androgenic, estrogenic, corticoid, and anabolic activities, and it is not metabolized into pregnanediol. Dydrogesterone plays a crucial role in maintaining a healthy uterine lining, which supports the treatment of various menstrual disorders, including amenorrhea, dysmenorrhea, infertility, premenstrual syndrome, and endometriosis.
Absorption
Dydrogesterone is rapidly absorbed through the gastrointestinal tract, with a bioavailability rate of approximately 28%.
Metabolism
The metabolism of dydrogesterone is comprehensive, resulting in the formation of a 20-dihydrodydrogesterone (DHD) metabolite.
Mechanism of Action
Dydrogesterone is a progestogen that functions by interacting with progesterone receptors within the uterus. This interaction plays a crucial role in regulating the healthy growth and normal shedding of the endometrial lining. Through its targeted action, Dydrogesterone effectively supports the maintenance of uterine health.
