EN171

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EN171

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Catalog Number	PR2191110797
CAS	2191110-79-7
Description	EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.
Synonyms	1-{7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one
IUPAC Name	1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one
Molecular Weight	270.37
Molecular Formula	C17H22N2O
Canonical SMILES	C=CC(=O)N1CCC2(C1)CCN(C2)CC3=CC=CC=C3
InChI	InChI=1S/C17H22N2O/c1-2-16(20)19-11-9-17(14-19)8-10-18(13-17)12-15-6-4-3-5-7-15/h2-7H,1,8-14H2
InChI Key	VKQVCQHCQMFBNJ-UHFFFAOYSA-N
Shipping	Shipping with blue ice.
Storage Conditions	Powder: Store at -20 °C for 3 years In solvent: -80 °C for 1 year

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