Gatifloxacin

Indications

Gatifloxacin is primarily indicated for the treatment of various bacterial infections, including·hitis, sinusitis, community-acquired pneumonia, and skin infections such as abscesses and wounds. This pharmaceutical agent is particularly effective against infections caused by bacteria such as S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, and S. pyogenes.

Pharmacodynamics

Gatifloxacin is classified as a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent available for both oral and intravenous administration. Its mechanism of action is bactericidal, relying·he inhibition of bacterial DNA replication. This is accomplished through the binding·he bacterial enzyme DNA gyrase, thereby preventing·he untwisting·he DNA double helix necessary for replication. This drug exhibits a notably higher affinity-100 times greater-for bacterial DNA gyrase compared to its affinity for mammalian equivalents. Gatifloxacin demonstrates broad-spectrum activity, targeting·h Gram-positive and Gram-negative bacteria, and should be reserved for infections that are confirmed or strong·have a bacterial origin.

Absorption

Upon oral administration, gatifloxacin is well absorbed from the gastrointestinal tract, exhibiting·his high level of absorption ensures that adequate therapeutic levels can be achieved systemically following·he human body. Less than 1% of the administered dose is metabolized and subsequently excreted in the urine as ethylenediamine and methylethylenediamine metabolites, indicating·hat the drug is largely excreted unchanged.