Iodixanol

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Iodixanol

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Catalog Number	PR92339112
CAS	92339-11-2
Description	Iodixanol is a dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography. It has a role as a radioopaque medium.
Synonyms	Visipaque; Indixanol; Iodixanolum
IUPAC Name	5-[acetyl-[3-[N-acetyl-3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
Molecular Weight	1550.2
Molecular Formula	C35H44I6N6O15
InChI	NBQNWMBBSKPBAY-UHFFFAOYSA-N
InChI Key	InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62)
Drug Categories	Acids, Carbocyclic; Benzene Derivatives; Benzoates; Compounds used in a research, industrial, or household setting; Contrast Media; Diagnostic Uses of Chemicals; Drugs that are Mainly Renally Excreted; Iodinated Contrast Agents; Iodobenzoates; Radiographic Contrast Agent; Roentgenography; Watersoluble, Nephrotropic, Low Osmolar X-Ray Contrast Media; X-Ray Contrast Activity; X-Ray Contrast Media, Iodinated
Drug Interactions	Abacavir-Abacavir may decrease the excretion rate of Iodixanol which could result in a higher serum level. Aceclofenac-Aceclofenac may decrease the excretion rate of Iodixanol which could result in a higher serum level. Acemetacin-Acemetacin may decrease the excretion rate of Iodixanol which could result in a higher serum level. Acetaminophen-Acetaminophen may decrease the excretion rate of Iodixanol which could result in a higher serum level. Acetazolamide-Acetazolamide may increase the excretion rate of Iodixanol which could result in a lower serum level and potentially a reduction in efficacy.
Isomeric SMILES	CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(=C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
Standard	USP
Type	Small Molecule
Therapeutic Category	Contrast Agent

Pharmacology

Indications

Iodixanol is primarily utilized as a contrast agent in coronary angiography. This application is essential for enhancing the clarity of images obtained, thereby aiding in the accurate diagnosis of coronary artery diseases.

Pharmacodynamics

Iodixanol operates as a contrast agent, predominantly in coronary angiography procedures. It is particularly advantageous for patients with renal impairment, as it is considered less nephrotoxic compared to most other intravascular contrast agents. Notably, Iodixanol maintains an osmolality equivalent to that of blood (290 mOsm/kg H2O), which contributes to its safer profile in vulnerable patient populations.

Metabolism

Iodixanol is excreted from the body unchanged.

Mechanism of Action

Iodixanol functions as a contrast agent by utilizing its iodine content to attenuate x-rays as they traverse the body. This attenuation results in enhanced delineation of body structures containing the iodine compound in comparison to those lacking it. The extent of opacity rendered by iodixanol is directly linked to the cumulative concentration and volume of the compound in the x-ray path. Upon intravascular administration, iodixanol enhances the opacity of internal structures along its flow path, facilitating their visualization until it undergoes significant hemodilution and elimination.

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