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K-Ras ligand-Linker Conjugate 5

Name: K-Ras ligand-Linker Conjugate 5
SKU: PR2378261857
Rating: 5 (1 reviews)

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Catalog NumberPR2378261857

CAS Number2378261-85-7

CategoryTarget Protein Ligand-Linker Conjugates

Description	K-Ras ligand-Linker Conjugate 5 is designed to facilitate the targeting and degradation of K-Ras proteins. By incorporating a specialized ligand for the K-Ras recruiting moiety and a PROTAC linker, this product effectively recruits E3 ligases, including VHL, CRBN, MDM2, and IAP. These interactions enable the synthesis of PROTAC K-Ras Degrader-1, a highly potent degrader that achieves at least 70% degradation efficacy in SW1573 cells.
Molecular Weight	789.96
Molecular Formula	C42H59N7O8
Canonical SMILES	O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
Purity	99.79%
Appearance	Solid
Storage	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Color	Light yellow to yellow
Shipping	Room temperature in continental US; may vary elsewhere.

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