LL-K12-18

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LL-K12-18

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Catalog Number	PR01258
Description	LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research.
Molecular Weight	559.49
Molecular Formula	C25H32Cl2N10O
Canonical SMILES	CCN1C=NC2=C1N=C(N(CC3)CCN3C(CN(CC)CC)=O)N=C2NCC4=NC5=CC(Cl)=C(C=C5N4)Cl
Purity	>98%
Appearance	White to off-white solid
Storage Conditions	Store at -20 °C

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