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MI-1063

Name: MI-1063
SKU: PR1410737391
Rating: 5 (1 reviews)

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Catalog NumberPR1410737391

CAS Number1410737-39-1

CategoryLigands for Target Protein for PROTAC

Description	MI-1063 serves as a potent inhibitor for DMD-2, disrupting the MDM2-p53 interaction to activate p53's tumor suppressor functions. It effectively inhibits the growth of cancer cells RS4-11 and MV4-11 with IC50 values of 179 nM and 93 nM, respectively. Additionally, MI-1063 can be utilized as a target protein ligand in the synthesis of PROTAC degrader MD-265, highlighting its valuable role in cancer research and treatment development.
Molecular Weight	588.50
Molecular Formula	C30H32Cl2FN3O4
Canonical SMILES	O=C(O)[C@H]1CC[C@@H](CC1)NC([C@@H]2NC3(CCCCC3)[C@]4(C5=CC=C(C=C5NC4=O)Cl)[C@H]2C6=CC=CC(Cl)=C6F)=O
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere.

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