NRX-2663

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NRX-2663

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Catalog Number	PR2763260348
CAS	2763260-34-8
Description	NRX-2663 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-2663 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome.
IUPAC Name	3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid
Molecular Weight	418.33
Molecular Formula	C20H13F3N2O5
Canonical SMILES	OC(=O)C1=CC=CC(NC(=O)C2=C(OC3=CC=CC=C3)C=C(NC2=O)C(F)(F)F)=C1
InChI	InChI=1S/C20H13F3N2O5/c21-20(22,23)15-10-14(30-13-7-2-1-3-8-13)16(18(27)25-15)17(26)24-12-6-4-5-11(9-12)19(28)29/h1-10H,(H,24,26)(H,25,27)(H,28,29)
InChI Key	QMARDTCIJVODCK-UHFFFAOYSA-N
Purity	≥95%
Solubility	DMSO, DMF
Appearance	White solid
Shipping	Room temperature
Storage Conditions	Refrigerated

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