Oxatomide
Oxatomide
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Oxatomide

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Catalog Number PR60607343
CAS 60607-34-3
Description Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist.
Synonyms Tinset; Celtect; Cobiona; Dasten
IUPAC Name 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
Molecular Weight 426.6
Molecular Formula C27H30N4O
InChI BAINIUMDFURPJM-UHFFFAOYSA-N
InChI Key InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
Documentation/Certification CEP
Drug Categories Anti-Allergic Agents; Anti-Asthmatic Agents; Antihistamines for Systemic Use; Histamine Agents; Histamine Antagonists; Histamine H1 Antagonists; Moderate Risk QTc-Prolonging Agents; Neurotransmitter Agents; Piperazine Derivatives; QTc Prolonging Agents; Respiratory System Agents
Drug Interactions Acrivastine-The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Oxatomide.
Adenosine-The risk or severity of QTc prolongation can be increased when Adenosine is combined with Oxatomide.
Ajmaline-The risk or severity of QTc prolongation can be increased when Ajmaline is combined with Oxatomide.
Albuterol-The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Oxatomide.
Alfuzosin-The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Oxatomide.
Isomeric SMILES C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C5
Type Small Molecule
Pharmacology

Mechanism of Action

Oxatomide functions as an antagonist of the histamine H1 receptor in humans. Its mechanism of action involves the inhibition of histamine binding to these receptors, thereby mitigating the physiological effects typically observed in the presence of histamine. By preventing this interaction, Oxatomide effectively alleviates symptoms associated with allergic reactions, such as inflammation and itching, contributing to its therapeutic efficacy in managing allergic conditions. This action places Oxatomide among a class of drugs used to counteract the histamine response in various hypersensitivity scenarios.

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