| Catalog Number |
PR3034673929 |
| CAS |
3034673-92-9 |
| Structure |  |
| Description |
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects. |
| IUPAC Name |
(2R,3S)-N-[(7S,13S)-21-ethyl-20-[2-[(1S)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,29-tetrazahexacyclo[17.5.2.12,5.19,13.110,12.022,26]nonacosa-1(25),2,5(29),19,22(26),23-hexaen-7-yl]-2,3-dimethylcyclopropane-1-carboxamide |
| Molecular Weight |
837.08 |
| Molecular Formula |
C46H60N8O5S |
| Canonical SMILES |
O=C1OCC(C)(CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC(N4CCN(C)CC4)=C3)N(CC)C5=CC=C(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8N[C@H]1C9CC8C9)=O)=N6)C=C25)C |
| InChI |
InChI=1S/C46H60N8O5S/c1-9-53-37-11-10-28-18-32(37)34(42(53)33-19-31(22-47-40(33)27(4)58-8)52-14-12-51(7)13-15-52)21-46(5,6)24-59-45(57)41-29-16-30(17-29)54(50-41)44(56)35(20-38-48-36(28)23-60-38)49-43(55)39-25(2)26(39)3/h10-11,18-19,22-23,25-27,29-30,35,39,41,50H,9,12-17,20-21,24H2,1-8H3,(H,49,55)/t25-,26+,27-,29?,30?,35-,39?,41-/m0/s1 |
| InChI Key |
DPKDQKDHUDKBNH-RUUSDHCJSA-N |
| Shipping |
Generally, shipped at room temperature in continental US; may vary elsewhere. |
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