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Poloxamer 188

Name: Poloxamer 188
SKU: PR9003116
Rating: 5 (1 reviews)

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Catalog NumberPR9003116

CAS Number9003-11-6

CategorySurfactants & Emulsifiers

Description	Poloxamer 188 is utilized as a pharmaceutical excipient primarily for its surfactant and emulsifying properties, aiding in the stabilization and solubilization of otherwise poorly soluble drug compounds. This nonionic triblock copolymer consists of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene, allowing it to enhance the bioavailability of active pharmaceutical ingredients (APIs) by improving their dispersion in aqueous environments. Its thermoreversible gelation features make it useful in controlled drug delivery systems, where it can modulate the release profiles of encapsulated therapeutics. Additionally, Poloxamer 188 acts as a lubricant and a wetting agent, minimizing friction and aiding in the uniform distribution of the drug within formulations, such as tablets and liquid dispersions. Its biocompatibility and low toxicity further augment its applicability across various dosage forms, including parenterals and ophthalmic preparations.
Synonyms	Polyethylene-Polypropylene Glycol; Pluronic F68
Molecular Formula	HO(C2H4O)a(C3H6O)b(C2H4O)aH
Grade	NF

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