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(Rac)-PROTAC PARP/EGFR ligand 1

Name: (Rac)-PROTAC PARP/EGFR ligand 1
SKU: PR2935073360
Rating: 5 (1 reviews)

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Catalog NumberPR2935073360

CAS Number2935073-36-0

CategoryTarget Protein Ligand-Linker Conjugates

Description	(Rac)-PROTAC PARP/EGFR ligand 1 is designed to serve as a multifunctional agent by integrating a ligand for PARP and EGFR along with a PROTAC linker. This unique construction enables the recruitment of E3 ligases, such as VHL, CRBN, MDM2, and IAP, to target specific proteins for degradation. The primary purpose of (Rac)-PROTAC PARP/EGFR ligand 1 is to facilitate the synthesis of DP-C-4, a CRBN-based dual PROTAC, which is used for the simultaneous degradation of EGFR and PARP, thereby offering a strategic approach for therapeutic interventions targeting these proteins.
Molecular Weight	1020.52
Molecular Formula	C53H56ClF2N9O8
Canonical SMILES	O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCNC(C(COCC#C)NC(CCCCCOC4=CC5=C(NC6=CC=C(C(Cl)=C6)F)N=CN=C5C=C4OC)=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere.

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