Thalidomide-d4

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Thalidomide-d4

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Catalog Number	PR1219177180
CAS	1219177-18-0
Structure
Description	Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
Synonyms	(+/-)-Thalidomide-d4 (phenyl-d4)
IUPAC Name	4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular Weight	262.25
Molecular Formula	C13H6D4N2O4
Canonical SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O
InChI	InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/i1D,2D,3D,4D
InChI Key	UEJJHQNACJXSKW-RHQRLBAQSA-N
Purity	>98%
Appearance	White to off-white solid
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at 4 °C

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