TMX-4116

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TMX-4116

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Catalog Number	PR2766385560
CAS	2766385-56-0
Description	TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.
Synonyms	3-{4-[4-methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl]-1H-1,2,3-triazol-1-yl}piperidine-2,6-dione
IUPAC Name	3-[4-[4-methoxy-5-(pyrrolidine-1-carbonyl)thiophen-3-yl]triazol-1-yl]piperidine-2,6-dione
Molecular Weight	389.43
Molecular Formula	C17H19N5O4S
Canonical SMILES	O=C(C(N1N=NC(C2=CSC(C(N3CCCC3)=O)=C2OC)=C1)CC4)NC4=O
InChI	InChI=1S/C17H19N5O4S/c1-26-14-10(9-27-15(14)17(25)21-6-2-3-7-21)11-8-22(20-19-11)12-4-5-13(23)18-16(12)24/h8-9,12H,2-7H2,1H3,(H,18,23,24)
InChI Key	OOIINFBRWZQRRM-UHFFFAOYSA-N
Purity	>99.5%
Appearance	Off-white to gray solid
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at 4 °C

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