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Trehalose dihydrate

Name: Trehalose dihydrate
SKU: PR6138234
Rating: 5 (1 reviews)

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Catalog NumberPR6138234

CAS Number6138-23-4

CategoryStabilizers

Description	Trehalose dihydrate serves the essential role of stabilizing biologic formulations by leveraging its unique chemical structure and properties. This specialized sugar consists of two glucose units connected by a robust α-1,1 bond, endowing it with stability under acidic and high-temperature conditions. Unlike other sugars, trehalose avoids glycation, thus preventing degradation of biologics. It effectively preserves protein therapeutics due to its cryoprotective properties and high glass transition temperature, around 115°C, which allows it to form a stable glassy state. This physical attribute minimizes molecular mobility, thereby reducing the risk of protein aggregation or denaturation, which can compromise therapeutic efficacy. Trehalose is particularly well-suited for protecting sensitive biologics during processes like freeze-drying and storage, ensuring the preservation of protein structure and function for therapeutic use. These formulations are ideal for use in protein-based therapeutics, modern lyophilization techniques, and inhalation medications. Furthermore, trehalose dihydrate demonstrates significant value in the preservation of monoclonal antibodies, fusion proteins, vaccines, and stem cells.
Molecular Weight	378.33
Molecular Formula	C12 H22O11 . 2H2O
Boiling Point	675.4 °C
Melting Point	96.5 °C
Solubility	in water: 68.9 g per 100 g at 20 °C
Application	Parenteral formulation; ophthalmic formulation; inhalation formulation; cryopreservation; lyophilization
Feature	High purity; lowest endotoxin; lowest metals; lowest bioburden; lowest nitrosamines
Grade	NF, EP, JP, ChP
Uses	Suitable for injectable biologics and vaccines, as well as inhaled and ophthalmic formulations.

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