| Description |
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). |
| Synonyms |
4-Butyl-1,2-diphenylpyrazolidine-3,5-dione; Butapirazol; Butazolidin; Butadion |
| IUPAC Name |
4-butyl-1,2-diphenylpyrazolidine-3,5-dione |
| Molecular Weight |
308.4 |
| Molecular Formula |
C19H20N2O2 |
| InChI |
VYMDGNCVAMGZFE-UHFFFAOYSA-N |
| InChI Key |
InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3 |
| Drug Categories |
Agents causing hyperkalemia; Agents that produce hypertension; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal (Non-Selective); Antiinflammatory and Antirheumatic Products; Antiinflammatory and Antirheumatic Products, Non-Steroids; Antiinflammatory Preparations, Non-Steroids for Topical Use; Antirheumatic Agents; Butylpyrazolidines; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors (strength unknown); Cytochrome P-450 CYP2C9 Substrates; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A4 Inducers; Cytochrome P-450 CYP3A4 Inducers (strength unknown); Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Substrates; Musculo-Skeletal System; Nephrotoxic agents; Non COX-2 selective NSAIDS; OAT1/SLC22A6 inhibitors; OAT3/SLC22A8 Inhibitors; Peripheral Nervous System Agents; Pyrazoles; Pyrazolones; Sensory System Agents; Topical Products for Joint and Muscular Pain |
| Drug Interactions |
Abacavir-Phenylbutazone may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abatacept-The metabolism of Phenylbutazone can be increased when combined with Abatacept.
Abciximab-The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Abciximab.
Abemaciclib-The metabolism of Abemaciclib can be increased when combined with Phenylbutazone.
Abrocitinib-The metabolism of Abrocitinib can be decreased when combined with Phenylbutazone. |
| Isomeric SMILES |
CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3 |
| Therapeutic Category |
Analgesics |
| Type |
Small Molecule |
