Indications
Sodium Borate, commonly referred to as boric acid, currently does not possess any therapeutic indications approved by the FDA or EMA. While it is frequently utilized in various applications due to its chemical properties, it should be noted that its use as a medicinal agent is not authorized by primary regulatory bodies.
Pharmacodynamics
Boric acid demonstrates mild bacteriostatic and antifungal properties. At elevated concentrations and with prolonged exposure, it is capable of exerting antifungal effects. However, these actions are limited and require specific conditions to be effective.
Absorption
Boric acid is efficiently absorbed through the gastrointestinal tract, open wounds, and serous cavities. In contrast, its absorption through intact skin remains minimal. In animal studies, particularly in mice, boric acid achieves peak concentration in the brain approximately 1.0 to 1.5 hours after intraperitoneal injection, whereas other tissues reach peak levels in about 0.5 hours.
Mechanism of Action
Sodium Borate acts primarily through the inhibition of key virulence factors in microorganisms. It effectively prevents biofilm formation and hyphal transformation in Candida albicans, both of which are essential for the pathogen's virulence. Furthermore, treatment with Sodium Borate has been observed to halt the growth of fungal cells, highlighting its potential as an antibacterial and antifungal agent.
